The Syrian War, which has spanned over a decade, has emerged as a focal point in the global discussion on the intersection of migration, terrorism, and international security. This paper explores the Syrian conflict through the lens of Samuel Huntington’s “Clash of Civilizations” theory, analyzing how cultural and religious divides have fueled the war and its global ramifications. The war’s impact on migration has been profound, triggering one of the largest refugee crises in history, while also leading to the rise of radicalized terrorist groups. These factors, in turn, have influenced international security policies and shaped global responses to both migration and terrorism. By examining the roots of the conflict, its migration-related challenges, and the terrorist activities it has spawned, this paper provides a comprehensive analysis of the Syrian war as a critical case study in the clash between Western and non-Western civilizations. The study also discusses the broader implications for global security, emphasizing the importance of understanding cultural and civilizational dynamics in conflict resolution and policy formulation.