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International Research Journal of Medical Sciences and Health Care

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Open Access

Contemporary Approaches to The Management of Inflammatory Breast Cancer in Primary and Secondary Settings

DOI https://doi.org/10.55640/irjmshc-v03i04-05
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Almuradova D.M. 1 ORCID iD , Ravshanova N.B. 1 ORCID iD , Almuradov A 1 ORCID iD , Sadullayeva N.I 1 ORCID iD ,
4 Associate Professor, PhD, Tashkent State Medical University, Uzbekistan
4 Oncologist, Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology, Tashkent, Republic of Uzbekistan
4 Associate Professor, PhD, Tashkent State University of Economics, Republic of Uzbekistan
4 Oncologist, Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology, Tashkent, Republic of Uzbekistan

Abstract

Breast cancer is the leading oncological disease among women in Uzbekistan, accounting for 24.9% of all cancer cases in 2022. Edematous-infiltrative (inflammatory) breast cancer (IBC) is a rare but highly aggressive subtype characterized by rapid progression, early metastasis, and poor prognosis.Objective: To develop and individualize treatment strategies for patients with primary and secondary inflammatory breast cancer.Materials and Methods: This retrospective study included 60 consecutive patients with immunohistochemically confirmed primary (n=22) and secondary (n=38) IBC treated between 2018 and 2022. Patients received either combined therapy (chemotherapy + radiotherapy) or multimodal therapy (chemotherapy + surgery + radiotherapy). Clinical, pathological, and molecular characteristics were analyzed. Survival outcomes were assessed using the Kaplan–Meier method.Results: In patients with PEV2, multimodal therapy demonstrated higher overall survival (OS: 36±8.5 months) compared to combined therapy (31±5.9 months). In contrast, in PEV3 patients, combined therapy showed superior outcomes (OS: 36±5.9 vs. 27±5.6 months). Combined therapy was more effective in primary IBC, while multimodal therapy showed better outcomes in secondary IBC.Conclusion: Treatment outcomes in IBC depend on disease form and extent of skin involvement. Personalized treatment strategies based on PEV classification and disease subtype may improve survival outcomes.

Keywords

Inflammatory breast cancer, PEV classification, chemotherapy

References

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