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International Research Journal of Medical Sciences and Health Care

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Molecular and Functional Recovery in Contused Muscle Tissues Treated with Betulin in Mice

DOI https://doi.org/10.55640/irjmshc-v02i06-01
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Dr. Maria S. Kovalenko 1 , Dr. Elena I. Smirnova 1 ,
4 Department of Pharmacology, Sechenov First Moscow State Medical University, Russia
4 Faculty of Biology, Lomonosov Moscow State University, Russia

Abstract

Muscle contusion injuries are common in trauma and sports medicine, often resulting in prolonged recovery and functional impairment. This study investigates the therapeutic efficacy of betulin—a natural pentacyclic triterpene—on the molecular and functional recovery of skeletal muscle following contusion injury in mice. Using a controlled murine injury model, betulin was administered post-injury, and recovery was evaluated through histological analysis, inflammatory marker profiling, and grip strength testing. The results revealed that betulin significantly reduced inflammation, promoted myofiber regeneration, and accelerated functional recovery compared to untreated controls. Molecular assays demonstrated upregulation of regenerative markers and downregulation of pro-inflammatory cytokines in treated tissue. These findings suggest that betulin facilitates both structural and functional muscle repair and holds promise as a novel therapeutic agent for soft tissue injuries.

Keywords

Beituln, muscle regeneration, contusion injury

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