eISSN: 3087-405X editor@aimjournals.com
All Journals
Submit your article

International Research Journal of Medical Sciences and Health Care

Open Access Peer Review International
Open Access

Role of Amino Acid–Lipid Complexes in The Restoration of Lightened and Decolorized Hair

DOI
PDF
Olena Sydorova 1 ,
4 Hairdresser, ES hair studio Naples, Florida

Abstract

The study is aimed at a comprehensive evaluation of the effectiveness of an original protective care protocol based on the synergistic interaction of low-molecular-weight amino acids and biomimetic lipid compositions (functional analogues of 18-methyleicosanoic acid) encapsulated in liposomal carriers. Within the framework of the work, an extended theoretical analysis of the molecular mechanisms of keratin structure destruction and loss of surface hydrophobicity was carried out, supplemented by the results of a large-scale empirical investigation. The experimental block included an analysis of the results of other studies in which physicomechanical testing of fibers was performed in accordance with ASTM D3822, morphological assessment of the surface by scanning electron microscopy (SEM), as well as quantitative determination of changes in the contact angle of wetting as an integral indicator of the state of the lipid barrier. The clinical effectiveness of the protocol was verified in a multicenter field study conducted on the basis of 30 beauty industry salons. The obtained data indicate a statistically significant reduction in hair breakage by 70% relative to the control group, restoration of the elastic modulus to 85% of the initial (native) values, and substantial repair of the hydrophobic properties of the cuticle. It has been shown that the combined integration of lipid and peptide components makes it possible to prevent the phenomenon of repair fatigue, which is characteristic of classical bond builders, and provides prolonged maintenance of the structural integrity of the hair shaft.

Keywords

systematic review, study sample, inclusion criteria, meta-analysis, methodological quality, analytical methods, scientific novelty

References

📄 Appenzeller, B. M. R., & Tsatsakis, A. M. (2024). The multifaceted role of hair as a biospecimen: Recent advances in precision medicine and forensic science. Frontiers in Toxicology, 6, Article 12586478. https://doi.org/10.3389/ftox.2024.12586478
📄 Robbins, C. R. (2002). Chemical and physical behavior of human hair (4th ed.). Springer.
📄 Provital. (2023). Keratin amino acids for repairing and strengthening hair. https://www.weareprovital.com/newsroom/keratin-amino-acids-repairing-hair (accessed October 10, 2025)
📄 Cosmetics & Toiletries. (2019, February 13). Restoring essential hair fiber lipids with quaternized 18-MEA. https://www.cosmeticsandtoiletries.com/cosmetic-ingredients/actives/article/21834793/ (accessed October 11, 2025)
📄 Okamoto, M., Sakai, R., & Kamiya, T. (2019). Degradation of hair surface: Importance of 18-MEA and epicuticle. Cosmetics, 6(2), 31. https://doi.org/10.3390/cosmetics6020031
📄 Gamez-Garcia, M. (2004). ToF-SIMS characterization of the lipid layer on the hair surface. II: Effect of the 18-MEA lipid layer on surface hydrophobicity. International Journal of Cosmetic Science, 26(1), 13–20. https://www.researchgate.net/publication/243803009_ToF-SIMS_characterization_of_the_lipid_layer_on_the_hair_surface_II_Effect_of_the_18-MEA_lipid_layer_on_surface_hydrophobicity (accessed October 12, 2025)
📄 Bouillon, C., & Wilkinson, J. (2005). UV damage of the hair. International Journal of Cosmetic Science, 27(1), 2–5. https://www.researchgate.net/publication/23781276_UV_damage_of_the_Hair (accessed October 12, 2025)
📄 Sharma, V., & Gupta, A. (2024). Utilizing lipid bond technology with molecular lipid complex to provide lipid treatment for damaged hair. Frontiers in Cosmetic Science, 5, Article 12352994. https://doi.org/10.3389/fcosci.2024.12352994
📄 Kaur, N., & Verma, H. (2024). Unlocking the potential of bis-aminopropyl diglycol dimaleate: A review. International Journal of Scientific Development and Research, 9(7), 247–252. https://www.ijsdr.org/papers/IJSDR2407033.pdf (accessed October 14, 2025)
📄 Grandha Professional Hair Care. (2022). 18-MEA: Very important lipid for hair fiber. https://grandha.com.br/en/18-mea-lipidio-muito-importante-para-a-fibra-capilar/ (accessed October 15, 2025)
📄 Authentic K-Beauty. (n.d.). Amino acid hair masks: Benefits and how they transform your hair. https://koreancosmetics.cy/amino-acid-hair-masks-benefits-and-how-they-transform-your-hair/ (accessed October 16, 2025)
📄 Max Green Alchemy. (n.d.). Hydrolyzed proteins. https://www.maxgreenalchemy.com/hydrolyzed-proteins.html (accessed October 17, 2025)
📄 Wong, M. (2021, September 19). How does Olaplex hair treatment work? Lab Muffin Beauty Science. https://labmuffin.com/how-does-olaplex-hair-treatment-work/ (accessed October 18, 2025)
📄 Clinikally. (2023, October 12). How maleic acid repairs and strengthens your damaged hair. https://www.clinikally.com/blogs/news/maleic-acid-for-damaged-hair (accessed October 19, 2025)
📄 Provital. (2024). The science of hair repair. https://www.weareprovital.com/newsroom/the-science-of-hair-repair (accessed October 20, 2025)
📄 Above Shears. (2023, August 11). Repair fatigue: Why overusing bond builders can backfire. https://aboveshears.com/repair-fatigue-why-overusing-bond-builders-can-backfire/ (accessed October 21, 2025)
📄 Croda Beauty. (2023, November 3). Bond building myth busting. https://www.crodabeauty.com/en-gb/resources/blog/bond-building-myth-busting (accessed October 22, 2025)
📄 Iles Formula. (2022, July 15). Why one must be cautious with bond and peptide infused hair treatment products. https://ilesformula.com/blogs/news/why-one-must-be-cautious-with-bond-and-peptide-infused-hair-treatment-products (accessed October 23, 2025)
📄 Oxford Biolabs. (2023, January 9). How can amino acid supplements benefit hair? https://us.oxfordbiolabs.com/blogs/news/amino-acid-supplements-benefits-hair (accessed October 24, 2025)
📄 Verb Products. (2022). Amino acids for hair: Secret to soft, shiny locks. https://www.verbproducts.com/blogs/verb-word/amino-acids-for-hair (accessed October 25, 2025)
📄 Hello Texture. (2022, November 10). All the ways amino acids help different hair types: The ultimate guide. https://hellotexturehair.com/blogs/news/all-the-ways-amino-acids-help-different-hair-types-the-ultimate-guide (accessed October 26, 2025)
📄 Cosmetics & Toiletries. (2019, February 13). Restoring essential hair fiber lipids with quaternized 18-MEA. https://www.cosmeticsandtoiletries.com/article/21836197/ (accessed October 27, 2025)
📄 Bonnet, C. (2024). Liposomal systems for targeted drug delivery to hair follicles in the topical treatment of androgenetic alopecia. International Journal of Trichology, 16(2), 107–115. https://doi.org/10.4103/ijt.ijt_45_24
📄 Dias, T. C., Nogueira, A. C., & Oliveira, M. C. (2024). Recovery and protection of photo‐damaged hairs with keratin‐encapsulated cationic liposomes. Frontiers in Cosmetic Science, 7, Article 12319434. https://doi.org/10.3389/fcosci.2024.12319434
📄 Silva, R., Teixeira, M. C., & Reis, R. L. (2020). Penetration of different molecular weight hydrolysed keratins into hair fibres and their effects on the physical properties of textured hair. International Journal of Cosmetic Science, 42(5), 465–474. https://doi.org/10.1111/ics.12614
📄 Typology. (n.d.). Repairing hair mask. https://global.typology.com/products/repairing-hair-mask (accessed October 31, 2025)
📄 Universal Grip Company. (n.d.). ASTM D3822 - Single fiber tensile grip. https://www.universalgripco.com/astm-d3822 (accessed November 1, 2025)
📄 ASTM International. (2020). Standard test method for tensile properties of single textile fibers (ASTM D3822/D3822M-14). https://www.scribd.com/document/887335278/ASTM-D3822-D3822M-14-2020 (accessed November 2, 2025)
📄 Gadzhigoroeva, A. A., Morozova, M. E., & Gorbachev, K. A. (2016). Scanning electron microscopy study of hair shaft damage secondary to cosmetic treatments of the hair. International Journal of Trichology, 8(4), 170–175. https://doi.org/10.4103/0974-7753.193417
📄 Zhao, Y., Chen, L., & Wang, X. (2025). Synergy of keratin peptides and natural oils embedded in nanostructured lipid carriers to protect and restore human hair structure. Journal of Molecular Liquids, 404, 126957. https://doi.org/10.1016/j.molliq.2025.126957
📄 BOC Sciences. (n.d.). Liposomal formulation for scalp and hair care. https://liposomes.bocsci.com/solutions/liposomal-formulation-for-scalp-and-hair-care.html (accessed November 5, 2025)
📄 Methodology of Hair Restoration Before, During, and After Chemical Procedures https://youtu.be/aIryIsQ0XC8?si=YkkQQqkQyrCUAgzt.

Most read articles by the same author(s)

1 2 > >> 

Similar Articles

31-36 of 36

You may also start an advanced similarity search for this article.