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International Research Journal of Medical Sciences and Health Care

Open Access Peer Review International
Open Access

Chemical Peels in Anti-Age Therapy

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Bagdasarian Goar Karenovna 1 ,
4 Beauty Salon Alexander Lvovich Volchenkov, Sole Proprietor Moscow, Russia

Abstract

Against the backdrop of the dynamic expansion of the aesthetic medicine segment, chemical peels retain their status as a fundamental tool in anti-aging therapy. The aim of this study is to systematically summarize the scientific literature, assessing the clinical efficacy, mechanisms of action, and safety profile of chemical peels, with an emphasis on their combination with mesotherapy for the correction of age-associated skin changes. A systematic review and comparative analysis of peer-reviewed clinical studies, meta-analyses, and industry reports indexed in Scopus, Web of Science, and PubMed over recent years was conducted. The results confirm the significant efficacy of alpha hydroxy acids (AHAs) and trichloroacetic acid (TCA) monotherapy in smoothing skin texture, reducing the appearance of wrinkles, and correcting discolorations. A key finding is the demonstrated synergy between peels and mesotherapy: clinical trials have documented a statistically significant superiority of the combined protocols compared to monotherapy in terms of skin hydration, elasticity, and overall skin quality. The comprehensive effect achieved by combining chemical peels and mesotherapy encompasses both epidermal and dermal structures, providing a more pronounced and lasting clinical effect. These data support the hypothesis and highlight the high practical significance of this approach. The presented materials are intended for dermatologists, cosmetologists, and aesthetic medicine specialists focused on optimizing anti-aging protocols.

Keywords

chemical peeling, anti-age therapy, photoaging, skin rejuvenation, trichloroacetic acid, glycolic acid, combination therapy, mesotherapy, neocollagenesis, dermatocosmetology

References

📄 Aesthetic Medicine Market Size, Share | Industry Report, 2033 - Grand View Research [Electronic resource]. - Access mode: https://www.grandviewresearch.com/industry-analysis/medical-aesthetics-market (date accessed: 20.10.2025).
📄 Aesthetic Medicine Market Size and Forecast 2025 to 2034 [Electronic resource]. - Access mode: https://www.precedenceresearch.com/aesthetic-medicine-market (date accessed: 20.10.2025).
📄 Aesthetic Medicine Market Size and Growth [Electronic resource]. - Access mode: https://www.novaoneadvisor.com/report/aesthetic-medicine-market (date accessed: 22.10.2025).
📄 State of Beauty 2025: Unlocking Growth in a Transforming Industry [Electronic resource]. - Access mode: https://nielseniq.com/global/en/insights/commentary/2025/state-of-beauty-2025/ (date accessed: 22.10.2025).
📄 Medical Aesthetics Market Size, Share & Industry Analysis, By Type (Energy-based Devices, Non-energy-based Devices, and Others), By Application (Skin Resurfacing & Tightening, Body Contouring and Cellulite Reduction, Hair and Tattoo Removal, Breast Augmentation, and Others), By End-user (Hospitals, Specialty Clinics, and Others), and Regional Forecast, 2024-2032 [Electronic resource]. - Access mode: https://www.fortunebusinessinsights.com/industry-reports/medical-aesthetics-market-100631 (date accessed: 22.10.2025).
📄 Raef H. et al. A History of the Advances in Chemical Peeling in Dermatologic Surgery Since 2000 //Dermatologic Surgery. – 2025. – Vol. 51 (9). – pp. 831-840.
📄 Rendon M. I. et al. Evidence and considerations in the application of chemical peels in skin disorders and aesthetic resurfacing //The Journal of clinical and aesthetic dermatology. – 2010. – Vol. 3 (7). – pp. 32–43.
📄 Steeb T. et al. Chemical peelings for the treatment of actinic keratosis: a systematic review and meta‐analysis //Journal of the European Academy of Dermatology and Venereology. – 2021. – Vol. 35 (3). – pp. 641-649. https://doi.org/10.1111/jdv.16844.
📄 Măgerușan Ș. E., Hancu G., Rusu A. A comprehensive bibliographic review concerning the efficacy of organic acids for chemical peels treating acne vulgaris //Molecules. – 2023. – Vol. 28 (20). https://doi.org/10.3390/molecules28207219.
📄 Karwal K., Mukovozov I. Topical AHA in dermatology: Formulations, mechanisms of action, efficacy, and future perspectives //Cosmetics. – 2023. – Vol. 10 (5). https://doi.org/10.3390/cosmetics10050131.
📄 Egli C. et al. The hydroxy acids: Where have we been and what's new? //Dermatological Reviews. – 2023. – Vol. 4 (6). – pp. 260-267. https://doi.org/10.1002/der2.217.
📄 S. Sitohang I. B. et al. Trichloroacetic acid peeling for treating photoaging: a systematic review //Dermatology research and practice. – 2021. – Vol.1.https://doi.org/10.1155/2021/3085670.
📄 Kubiak M. et al. Evaluation of 70% glycolic peels versus 15% trichloroacetic peels for the treatment of photodamaged facial skin in aging women //Dermatologic Surgery. – 2014. – Т. 40. – №. 8. – С. 883-891. https://doi.org/10.1097/01.DSS.0000452669.84787.bf.
📄 Kumari R., Thappa D. M. Comparative study of trichloroacetic acid versus glycolic acid chemical peels in the treatment of melasma //Indian Journal of Dermatology, Venereology and Leprology. – 2010. – Vol. 76. https://doi.org/10.4103/0378-6323.66602.
📄 Markiewicz-Tomczyk A., Budzisz E., Erkiert-Polguj A. A subjective and objective assessment of combined methods of applying chemical peels and microneedling in antiaging treatments //Journal of Clinical Medicine. – 2023. – Vol. 12 (5). https://doi.org/10.3390/jcm12051869.
📄 Woźna J. et al. Chemical peeling in combination with microneedling versus chemical peeling or microneedling monotherapy in the treatment of acne scars: a systematic review and meta-analysis //Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. – Vol. 42 (1). – pp. 1-10. https://doi.org/10.5114/ada.2025.154436
📄 Riekie S. Evaluation of the Efficacy of a TCA Medium Peeling Procedure Combined With Skin Biorevitalization in Face Rejuvenation: A Case Series //Journal of Dermatology & Cosmetology. – 2024. – Vol. 8. – pp. 35-39.
📄 Munshi M. et al. The efficacy and safety of trichloroacetic acid in the treatment of solar lentigo: a systematic review and meta-analysis //Archives of Dermatological Research. – 2025. – Vol. 317 (1). – pp. 1-9.
📄 Domela Nieuwenhuis I. et al. Assessment of patient satisfaction with appearance, psychological well-being, and aging appraisal after upper blepharoplasty: a multicenter prospective cohort study //Aesthetic Surgery Journal. – 2022. – Vol. 42 (4). – pp. 340-348. https://doi.org/10.1093/asj/sjab389.
📄 Almeman A. A. Evaluating the efficacy and safety of alpha-hydroxy acids in dermatological practice: A comprehensive clinical and legal review //Clinical, Cosmetic and Investigational Dermatology. – 2024. – pp. 1661-1685. https://doi.org/10.2147/CCID.S453243.
📄 Wambier C. G. et al. Advanced chemical peels: phenol-croton oil peel //Journal of the American Academy of Dermatology. – 2019. – Vol. 81 (2). – pp. 327-336. https://doi.org/10.1016/j.jaad.2018.11.060.
📄 Khunger N., Chanana C. A perspective on what’s new in chemical peels //Cosmoderma. – 2022. – Vol. 2. – pp. 1-8.
📄 Vidal S. I., Menta N., Friedman A. All Things Acids: A Primer on Alpha Hydroxy, Beta Hydroxy, and Polyhydroxy Acids //Journal of drugs in dermatology: JDD. – 2025. – Vol. 24 (5). – pp. 549-550.
📄 Siddiqui Z. et al. Comparing tretinoin to other topical therapies in the treatment of skin photoaging: a systematic review //American Journal of Clinical Dermatology. – 2024. – Vol. 25 (6). – pp. 873-890.
📄 Tran D. et al. An antiaging skin care system containing alpha hydroxy acids and vitamins improves the biomechanical parameters of facial skin //Clinical, cosmetic and investigational dermatology. – 2014. – pp. 9-17.
📄 Puri N. Comparative study of 15% TCA peel versus 35% glycolic acid peel for the treatment of melasma //Indian dermatology online journal. – 2012. – Vol. 3 (2). – pp. 109-113. https://doi.org/10.4103/2229-5178.96702.
📄 Javed Z. et al. Comparative Study of 35% Glycolic Acid (GA) Peel versus 15% Trichloroacetic Acid (TCA) in Patients Primed with 4% Hydroquinone and Sun Block for the Treatment of Melasma //Pakistan Armed Forces Medical Journal. – 2023. – Vol. 73 (2). – pp. 1-4.
📄 Combining Microneedling with Other Skin Treatments - Lyfe Aesthetics & MedSpa [Electronic resource]. - Access mode: https://mylyfemedspa.com/combining-microneedling-with-other-treatments/ (date accessed: 25.10.2025).

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