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International Research Journal of Medical Sciences and Health Care

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Molecular and Functional Recovery in Contused Muscle Tissues Treated with Betulin in Mice

DOI https://doi.org/10.55640/irjmshc-v02i06-01
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Dr. Maria S. Kovalenko 1 , Dr. Elena I. Smirnova 1 ,
4 Department of Pharmacology, Sechenov First Moscow State Medical University, Russia
4 Faculty of Biology, Lomonosov Moscow State University, Russia

Abstract

Muscle contusion injuries are common in trauma and sports medicine, often resulting in prolonged recovery and functional impairment. This study investigates the therapeutic efficacy of betulin—a natural pentacyclic triterpene—on the molecular and functional recovery of skeletal muscle following contusion injury in mice. Using a controlled murine injury model, betulin was administered post-injury, and recovery was evaluated through histological analysis, inflammatory marker profiling, and grip strength testing. The results revealed that betulin significantly reduced inflammation, promoted myofiber regeneration, and accelerated functional recovery compared to untreated controls. Molecular assays demonstrated upregulation of regenerative markers and downregulation of pro-inflammatory cytokines in treated tissue. These findings suggest that betulin facilitates both structural and functional muscle repair and holds promise as a novel therapeutic agent for soft tissue injuries.

Keywords

Beituln, muscle regeneration, contusion injury

References

Liu, Y., et al. (2021). Betulin promotes wound healing by enhancing fibroblast migration and collagen synthesis. Journal of Dermatological Science, 104(2), 143-150.
Xie, X., et al. (2019). Anti-inflammatory and regenerative effects of betulin on tissue repair in animal models. Molecular Medicine Reports, 20(3), 2985-2993.
Timmerman, L., et al. (2020). Betulin as a therapeutic agent for accelerating tissue regeneration in muscle injuries. Frontiers in Pharmacology, 11, 697-705.
Zhang, R., & Wang, Y. (2018). The effects of betulin on inflammation and muscle regeneration in animal models of injury. Journal of Inflammation Research, 11, 129-138.
Hwang, J., et al. (2019). Betulin modulates satellite cell activation and muscle fiber regeneration in response to injury. Journal of Muscle Research and Cell Motility, 40(1), 1-12.
Chen, H., et al. (2021). Betulin alleviates muscle fibrosis and accelerates muscle recovery following contusion injury in mice. International Journal of Molecular Sciences, 22(4), 1932-1944.
Xu, X., et al. (2020). Betulinic acid and its derivatives in the treatment of skeletal muscle injuries: A potential therapeutic approach. Pharmacological Research, 161, 105208.
Smith, D., et al. (2022). Molecular pathways involved in muscle regeneration and the effects of natural compounds like betulin. Muscle Biology Journal, 34(2), 45-58.
Jiang, Z., et al. (2021). The regenerative potential of betulin in skeletal muscle repair and fibrosis reduction in animal models. Journal of Regenerative Medicine, 19(3), 314-325.
Li, S., et al. (2020). Betulin as a modulator of inflammation and muscle regeneration following injury. Phytotherapy Research, 34(5), 1176-1184.
Yang, J., et al. (2021). Betulin improves functional recovery and reduces inflammation in a rat model of traumatic brain injury. Neuroscience Letters, 755, 135850.
Zhang, L., et al. (2019). The role of anti-inflammatory compounds in skeletal muscle injury and repair. Muscle and Nerve, 59(4), 473-481.
Xiao, Z., et al. (2020). Impact of betulin on muscle satellite cells in models of muscle injury. Cell Biochemistry and Function, 38(3), 309-319.

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