RADIOBIOLOGICAL AND BIOPHYSICAL CHARACTERIZATION OF MACROVIPERA LEBETINA OBTUSA VENOM
Abstract
The venom of Macrovipera lebetina obtusa has garnered significant attention due to its potent bioactive properties and potential therapeutic applications. This study provides a comprehensive radiobiological and biophysical characterization of the venom, aiming to elucidate its effects on cellular structures and its interaction with biological membranes. Through a series of in vitro experiments, we investigated the venom's cytotoxicity, genotoxicity, and its ability to induce oxidative stress in various cell lines. Additionally, advanced biophysical techniques, including circular dichroism spectroscopy and dynamic light scattering, were employed to analyze the conformational stability and aggregation behavior of venom proteins under different environmental conditions.
Our findings reveal that M. lebetina obtusa venom exhibits significant radiobiological activity, inducing DNA damage and altering cellular viability in a dose-dependent manner. The biophysical analysis further highlights the structural complexity of the venom's protein components, which undergo conformational changes upon interaction with lipid membranes. These insights contribute to a deeper understanding of the venom's mechanism of action at the molecular level and its potential implications in radiobiology and biophysics. The study also opens avenues for exploring the venom's application in developing novel therapeutic agents and improving radioprotective strategies.
Keywords
Macrovipera lebetina obtusa, venom, radiobiological effects, biophysical propertiesHow to Cite
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References
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