The increasing global dependence on synthetic chemical pesticides has resulted in significant ecological degradation, pest resistance development, and adverse effects on non-target organisms, necessitating sustainable alternatives for crop protection. This paper presents an integrated modeling and optimization framework for plant-derived bioinsecticides combined with green nanotechnology approaches to achieve environmentally safe pest management. Drawing on established biopesticide research and advancements in nanomaterial synthesis, the study synthesizes biological efficacy, nanoparticle functionalization, and ecological safety constraints into a unified conceptual system. Biopesticides derived from botanical sources are evaluated for their insecticidal mechanisms, while green-synthesized nanoparticles are analyzed for their role in enhancing delivery efficiency, stability, and targeted pest toxicity. The integration of these systems is further optimized through environmental impact constraints, efficacy-performance trade-offs, and sustainability indicators. Findings indicate that hybrid formulations significantly improve pest control efficiency while reducing chemical load and environmental toxicity. The study contributes a structured theoretical model for decision-making in sustainable agriculture and highlights critical research gaps in large-scale deployment, ecological risk assessment, and formulation standardization. The proposed framework supports future development of scalable, eco-safe pest management systems aligned with global food security and environmental conservation goals.